The Orville: Seth MacFarlane is like Henny Youngman: "Take my wife -- please!" His humor is an ill-fit for a show that ultimately tries to have a serious (or semi-serious) adventure-of-the-week format. It diminishes the main character (MacFarlane) as the captain of a ship with all those lives depending on him. He should have gone for complete anarchy in his approach to the "Star Trek Universe". Instead he's trying to eat his cake and have it too. That won't work. He has to decide where he wants the show to be, because right now it's schizophrenic. It looks like a bunch of fan-boys hit the lottery and then decided to write and produce their own version of their favorite TV show, and pepper it periodically with frat-boy humor. Plus, there's something decidedly uncharismatic about MacFarlane as an actor. I think he just doesn't exude any gravitas. I can't quite put my finger on it, but I think he's far more suited as a supporting actor than a leading man.
His humor works in an animated format. It doesn't with real people, unless he goes all-in on the crazy, over-exuberant style he's perfected with his animated shows.